肠道微生物群与肺炎风险之间的关联:系统性审查和门德尔随机化
Qingping Deng1, Yuanyuan Liu2, Hui Rong2
1State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, Guangdong 510120, China.
这项研究揭示了与COVID-19严重程度相关的特定肠道细菌. 某些微生物增加了风险,而其他微生物,如牛杆菌,在不同疾病阶段提供保护.
科学领域:
- 微生物组研究 微生物组研究
- 传染病流行病学 传染病流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 肠肺轴与COVID-19病变发生有关.
- 肠道微生物群的组成和代谢物可能会影响COVID-19的严重程度.
- 门德尔随机化 (MR) 为研究因果关系提供了一个工具.
研究的目的:
- 进行对MR研究的元分析,检查肠道微生物群和COVID-19严重程度之间的因果关系.
- 为了确定特定的肠道微生物种群和与不同层次的COVID-19严重程度相关的代谢物.
主要方法:
- 系统审查符合PRISMA 2020指南的MR研究.
- 来自11项研究 (32,748,274名参与者;1,487名SNP) 的数据的元分析.
- 通过四个COVID-19严重程度层进行分析:易感性,感染,住院和严重疾病.
主要成果:
- 像Actinobacteria和Negativicutes这样的特定细菌与增加的COVID-19易感性和严重性有关.
- 观察到Oxalobacter和RuminococcaceaeUCG014对COVID-19易感性的保护作用.
- 严重程度的相关风险因素包括Actinobacteria,Negativicutes和Alloprevotella;Oxalobacter和Parasutterella显示出保护作用.
结论:
- 强有力的证据支持肠道微生物群对COVID-19结果的严重程度特定因果关系.
- 已识别的微生物种群和代谢物作为风险分层的潜在生物标志物.
- 这些发现表明,COVID-19管理中的辅助治疗策略具有新的目标.
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