甘拉丁减轻了环境压力引起的氧化损害,在皮肤角质细胞中
Herath Mudiyanselage Udari Lakmini Herath1, Mei Jing Piao1, Kyoung Ah Kang1
1College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea.
International journal of medical sciences
|September 17, 2025
概括
甘是天然的黄类化合物,可以保护皮肤细胞免受空气污染 (PM2.5) 和紫外线辐射造成的损伤. 它通过抑制MAPK信号通路来减少氧化应激和亡,这表明它可以用于护肤.
科学领域:
- 皮肤病学 皮肤病学
- 环境科学 环境科学
- 生物化学 生物化学
背景情况:
- 颗粒物2.5 (PM2.5) 和紫外线 (UV) 辐射是引发皮肤损伤的环境压力因素.
- 对PM2.5和UVB的联合暴露会导致皮肤细胞的氧化应激和亡.
- 甘,一种黄类化合物,具有抗氧化特性,但其对联合PM2.5和UVB暴露的保护作用尚不清楚.
研究的目的:
- 调查加兰对PM2.5-和UVB诱导的氧化应激和人类角质细胞的亡的保护作用.
- 阐明加拉保护作用的基本机制,特别是它对MAPK信号通路的影响.
主要方法:
- 人类HaCaT角质细胞先用加兰进行预处理,然后暴露于PM2.5和/或UVB.
- 评估了细胞内活性氧物种 (ROS),脂质过氧化,蛋白质氧化,DNA损伤和线粒体损伤.
- 通过流动细胞计,共聚焦显微镜和西部涂抹,评估了亡性蛋白质表达,细胞亡和线粒激活蛋白激酶 (MAPK) 信号通路.
主要成果:
- 甘拉丁显著降低了ROS水平,脂质过氧化,蛋白质氧化,DNA损伤和由PM2.5和/或UVB引起的线粒体损伤.
- 甘巴林抑制了与亡相关的蛋白质的上调调节,并恢复了抗亡蛋白质的表达.
- 暴露于PM2.5和/或UVB激活了MAPK信号通路,导致细胞亡的增加. 甘,与MAPK抑制剂结合,进一步增强了保护.
结论:
- 甘达林对PM2.5-和UVB诱导的皮肤细胞损伤具有显著的保护作用.
- 甘拉丁的保护机制涉及抑制MAPK信号通路.
- 甘愿可能是护肤产品中一种有价值的成分,可以减轻环境压力引起的皮肤损伤.
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