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在患有复发性复发性多发性硬化症的患者中,选择的大脑结构的认知功能障碍和变
Małgorzata Szymańska1, Maciej Świat2, Monika Adamczyk-Sowa1
1Department of Neurology Zabrze, Medical University of Silesia in Katowice, Poland.
Postepy psychiatrii neurologii
|September 17, 2025
概括
大脑体积的变化与早期多发性硬化症 (MS) 患者的认知障碍相关. 早期的神经心理测试可以帮助选MS的认知功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响认知功能.
- 早期发现认知障碍对于管理MS至关重要.
- 大脑的结构变化,特别是缩,与MS的进展有关.
研究的目的:
- 将神经心理测试结果与新诊断的多发性硬化症患者的大脑体积测量结果进行比较.
- 研究大脑缩和疾病发病时的认知缺陷之间的关系.
- 为了确定未来纵向研究的基线相关性.
主要方法:
- 76名新诊断的MS患者接受了神经心理测试 (MSFC,EDSS,认知电池) 和脑MRI.
- 卷度MRI评估皮质和皮下结构.
- 评估是在治疗前和12个月后的基线进行的.
主要成果:
- 在灰质/皮质体积和认知测试 (PASAT3,SRT,BVMT-RD,BVMT-R) 之间发现了正相关性.
- 大脑缩与特定的认知障碍相关,表明结构认知联系.
- 在基线认知功能障碍严重程度和MS持续时间之间没有显著的相关性.
结论:
- 在MS患者中,从疾病发作开始,应早期评估认知领域.
- 对认知变化的长期跟踪至关重要.
- 评估经常受损的认知领域可以作为MS相关认知功能障碍的查工具.
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