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高血压加速衰老:来自NHANES数据库和孟德尔随机化分析的证据
Zhaobin Sun1, Gaoying Dai1, Nanhu Quan1
1Department of Cardiology, The First Hospital of Jilin University, Changchun, China.
Clinical and experimental hypertension (New York, N.Y. : 1993)
|September 17, 2025
概括
高血压 (高血压) 加快了生物衰老,增加了PhenoAge及其加速. 这项研究提供了高血压和多种衰老指标之间因果关系的证据,包括表观遗传衰老.
科学领域:
- 老年学是指老年学的学科.
- 心血管疾病 心血管疾病
- 遗传学 是一个遗传学.
背景情况:
- 人们怀疑高血压会加速生物衰老,但因果证据有限.
- 了解这种联系对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究高血压和生物衰老之间的关系.
- 提供高血压对衰老过程的因果关系的证据.
主要方法:
- 对2005-2010年国家健康和营养检查调查 (NHANES) 数据的分析.
- 权重多变量调整的线性回归来评估高血压与PhenoAge和PhenoAge加速的关联.
- 两个样本的孟德尔随机化 (MR) 使用全基因组关联研究数据推断DNA甲基化 (DNAm) 的因果关系,年龄加速,端粒长度,脆弱指数和面部衰老.
主要成果:
- 在NHANES数据中,高血压与增加的PhenoAge (β=12,p<0.001) 和PhenoAge加速 (β=0.56,p=0.009) 有显著的关联.
- 核磁共振分析表明高血压和DNAm PhenoAge加速 (OR=1.31,p<0.05),DNAm GrimAge加速 (OR=1.33,p<0.05) 和脆弱指数 (OR=1.09,p<0.05) 之间存在因果关系.
- 敏感性分析证实了这些发现的可靠性.
结论:
- 高血压与生物年龄 (PhenoAge) 的增加及其加速有关.
- 这项研究表明高血压和表观遗传衰老标志物之间存在潜在的因果关系.
- 这些发现突显了高血压对加速衰老过程的影响.
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