多种成分的补充剂,用于对抗缩症和多发病症
Joshua P Nederveen1,2, Mats I Nilsson3, Mark A Tarnopolsky3,2
1Department of Kinesiology, McMaster University.
Current opinion in clinical nutrition and metabolic care
|September 17, 2025
概括
多种成分的补充剂与抵抗训练相结合,有效地治疗了sarcopenia和sarcopenic肥胖症. 这些配方,特别是那些含有牛奶蛋白,肌酸和必需微量营养素的配方,显示出优越的肌肉生长效益,而不是单一成分的选择.
科学领域:
- 老年学和营养科学研究
- 骨肌肉生理学 骨肌肉生理学
- 运动医学和补充剂
背景情况:
- 骨肌肉病理,如sarcopenia和sarcopenic肥胖症在治疗中存在复杂的挑战.
- 营养药在管理与年龄相关的肌肉衰退和相关疾病方面发挥着越来越重要的作用.
- 了解单成分与多成分补充剂的疗效对于优化治疗策略至关重要.
研究的目的:
- 审查目前关于治疗肉症和肉性肥胖症 (SO) 的营养药物的文献.
- 评估多成分补充剂 (MIS) 在治疗复杂的骨肌肉 (SkM) 病理方面的潜力.
- 为了比较单一成分与多成分蛋白质制剂的有效性.
主要方法:
- 对抗性训练 (RT) 和蛋白质补充的元分析和随机对照试验 (RCT) 的系统审查.
- 对调查单成分补充剂 (如乳清,肌酸,维生素D3,,n-3PUFA) 和MIS的研究分析.
- 在sarcopenic群体中对SkM类别的代谢和身体成分变化的证据的评估.
主要成果:
- 分析证实了RT与蛋白质补充的协同效益,具有潜在的蛋白质上限效应.
- 单一成分的补充剂,如乳清蛋白,素和肌酸单酸,显示了与RT的证明好处.
- 实验室试验表明,乳清基MIS优于安慰剂,可以在各种人群中增强SkM的生长,包括患有sarcopenia的人群.
结论:
- 阻力训练 (RT) 是对肉类的主要治疗方法,改善肌肉质量,力量和功能.
- 增加蛋白质摄入量补充了RT,增强了肌肉类育化.
- 基于多种成分的蛋白质补充剂显示出优越的疗效,相比单一成分的选择,对萨尔科佩尼亚和SO管理.
相关概念视频
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
01:31Essential Minerals for Bone Health
6.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.0K
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
01:19The Effect of Aging on Tissues
3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
197
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
197
01:15Drug Dosing: Geriatric Patients
228
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
228