老年人的长期血压变化和身体表现
Kerry M Sheets1,2, Katherine L Webb3, Robyn L Woods3
1Department of Medicine, Hennepin Healthcare, Minneapolis, Minnesota, USA.
Journal of clinical hypertension (Greenwich, Conn.)
|September 17, 2025
概括
高血压变化 (BPV) 与步行速度减慢和握力减弱有关,特别是在男性中. 准BPV可能有助于在老年人群中保持身体功能.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 神经学 神经学
背景情况:
- 高血压变性 (BPV) 独立预测心血管疾病和认知衰退.
- 增加的BPV和下降的体力表现可能共享潜在的机械路径.
- BPV与步行速度和握力等身体表现指标之间的关联仍未得到充分研究.
研究的目的:
- 研究压缩和压缩血压变化 (SBPV和DBPV) 与身体表现 (步行速度和握力) 之间的联系.
- 进行性别分层分析,以了解这些关联中的潜在性别差异.
主要方法:
- 从ASPREE/ASPREE-XT研究中对16,692名参与者的性别分层分析.
- 在基线2年 (Y2) 估计了缩和腹缩BPV.
- 步行速度和握力被纵向评估,轨迹被使用线性混合模型分析,平均时间为7.3年.
主要成果:
- 在男性和女性中,较高的SBPV与横截面步行速度较慢有关.
- 随着时间的推移,SBPV较高的男性的步行速度和握力下降更大.
- 与男性相比,SBPV较高的女性的横截面握力较弱,但降低的速度与男性相似.
结论:
- 升高的血压变化独立地与较差的体力表现有关,特别是步行速度较慢和握力较弱.
- 在男性中,BPV对身体表现下降的影响似乎更为明显.
- 未来的研究应该考虑高BPV作为一个潜在的治疗目标,以维持老年人的身体功能.
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