饮食模式,肠道微生物群多样性和症严重程度之间的关联在患有亚托皮炎的学龄前儿童中:一个横截面研究
Jisu Park1, Soo Jin Lee1, Jing Yan1
1Department of Food Science and Nutrition & Kimchi Research Institute, Pusan National University, Busan, Korea.
概括
在患有亚托皮性皮炎 (AD) 的学龄前儿童中,加工食品和零食饮食与像多雷亚和Anaerostipes这样的肠道细菌有关,恶化了AD的严重程度和生活质量. 饮食改变可能有助于管理儿童早期的AD.
科学领域:
- 微生物组研究的研究.
- 儿科皮肤学 儿科皮肤学
- 营养科学 营养科学
背景情况:
- 饮食,肠道微生物群和疾病之间的关系在婴儿中是众所周知的,但其对学龄前皮炎 (AD) 的影响尚不清楚.
- 这项研究侧重于韩国儿童的饮食-肠道-皮肤轴,这些儿童患有AD.
研究的目的:
- 研究韩国学龄前儿童的饮食模式,肠道微生物群组成和亚托皮炎 (AD) 严重程度之间的关联.
- 通过饮食变化探索肠道微生物群调节在治疗儿科阿尔茨海默病的潜在作用.
主要方法:
- 评估了75名3-6岁的学龄前儿童 (24名患有AD,51名对照).
- 使用湿疹区域和严重性指数 (EASI) 和SCORing Atopic Dermatitis (SCORAD) 评估AD严重程度,并使用儿童皮肤病生命质量指数 (CDLQI) 评估生活质量.
- 使用16S rRNA测序来表征肠道微生物群,并用线性差异分析效应大小 (LEfSe) 分析群体差异.
主要成果:
- 饮食模式被分为传统韩国 (TK) 和加工食品和零食 (PS) 饮食.
- 在PS饮食中患有阿尔茨海默病的儿童的维生素C摄入量较低,多雷亚和无气体类型的水平较高,与增加和生活质量降低有关.
- 较低的维生素C摄入量与较高的Anaerostipes和Dorea丰度相关,并增加了AD严重程度得分 (EASI,SCORAD).
结论:
- 患有阿兹海默症的学龄前儿童的饮食中富含加工食品和零食的饮食与特定的肠道细菌 (Dorea,Anaerostipes) 相关,增加了阿兹海默症的严重程度,并降低了生活质量.
- 这些发现表明,针对饮食-肠-皮肤轴的饮食修改可能是缓解儿童早期AD的临床症状的潜在策略.
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