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长时间的胃肠保留的中孔载体

Enyun Xing¹, Yan Yu¹, Kui Yan¹

¹Department of Chemistry, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.

Journal of the American Chemical Society

|September 17, 2025

概括

一种新型的口服药物输送系统使用动态固的托特线载体来精确治疗胃肠道疾病. 这种智能平台可以提高药物在炎症部位的保留和释放,

科学领域:

生物材料科学
纳米技术
药物输送系统

背景情况:

精确的局部化,长时间的保留和有针对性的释放是口服药物的关键挑战,特别是对于炎症性肠病 (IBD) 等胃肠道疾病.
现有的系统通常在复杂的肠道内与特定场所的作用作斗争.

研究的目的:

开发一个以鱼为灵感的智能口服药物输送平台,以加强肠道向治疗.
针对IBD等疾病的精确局部化,长时间保留和按需释放药物的局限性.

主要方法:

设计了一种以步行线为灵感的生物粘合载体 (CNT@PMOs),采用碳纳米管 (CNTs) 装饰中性有机 (PMO) "".
药物 (例如,用于IBD的5-aminosalicylic酸) 被装入PMO中位孔中.
用于控制激活和释放,施加了对活性氧物种 (ROS) 敏感的聚合物涂层.

主要成果:

这种对ROS敏感的涂层在健康的胃肠道区域屏蔽了载体,并在高ROS水平的炎症部位降解.
暴露的PMO可以选择性粘附于炎症组织,延长局部药物保留时间.
实现了药物释放的控制和与粘膜的增强机械互锁,从而产生特定部位的治疗作用.

结论:

这种口服药物输送平台成功地整合了刺激反应激活,动态定和时空药物释放.
这种系统克服了口服药物输送的关键障碍,为提高肠道向治疗的治疗精度和有效性提供了广泛适用的策略.
该平台的系统暴露最小,便分泌量高,表明安全性较好.

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