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确定TDP-43的N端和RNA结合域之间的相互作用

David D Scott1, Lipsa Jena1,2, Akash Rajaram1

  • 1Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, USA.

Protein science : a publication of the Protein Society
|September 17, 2025
PubMed
概括

TAR DNA 结合蛋白 43 (TDP-43) 的 N-终端域 (NTD) 与其 RNA 识别基因 (RRMs) 相互作用,影响 RNA 结合. 这种NTD-RRM交互对于理解TDP-43至关重要.

关键词:
在CPMG的NMR中.HSQC-NMR域间相互作用在MST上,我们可以使用MST.在TDP-43中.

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