人类甲虫原体及其对发育中的大脑的影响的综述:来自 ConcePTION 项目的贡献
M Bluett-Duncan1, J Adams2, M Berkovitch3
1Division of Neuroscience, School of Biological Sciences, The University of Manchester, Manchester, UK.
Birth defects research
|September 17, 2025
概括
导致身体出生缺陷的药物也经常影响大脑发育. 对这些神经发育风险的研究被推迟了,这表明对孕妇的药物安全监测效率低下.
科学领域:
- 药理学 药理学是指药理学的学科.
- 发育毒理学 发展毒理学
- 神经科学是一个神经科学.
背景情况:
- 怀孕期间的药物可以影响产前发育,特别是大脑.
- 从历史上看,尽管存在已知的风险,但子宫内暴露对神经发育的影响尚未得到充分研究.
- 造成物理出生缺陷的结构性原体也可能构成神经发育风险.
研究的目的:
- 系统地审查与药物相关的神经发育结果,这些药物已确立具有物理原性作用.
- 综合研究特征,并确定药物诱导的神经发育变化的研究中的差距.
- 评估当前药物监测对识别神经发育风险的效率.
主要方法:
- 发表文献的范围审查.
- 在MEDLINE和EMBASE搜索24种已识别的结构性原体暴露后神经发育结果的研究.
- 包括经验队列和报告神经发育数据的病例系列.
主要成果:
- 在24种结构性原体中,只有13种 (54%) 已被研究其神经发育影响.
- 药物授权和神经发育结果研究之间存在显著的延迟 (平均33年).
- 当调查时,77%的暴露显示了神经发育结果的改变.
结论:
- 目前的药物监测系统在检测已知结构性原性药物的神经发育风险方面效率低下.
- 在评估神经发育影响方面存在大量的延迟,导致长时间的风险暴露.
- 神经发育变化的高患病率需要在怀孕期间改善和及时进行药物安全性评估.
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