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Updated: Jan 17, 2026

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BOP2-FE:贝叶斯最优的第二阶段设计与徒劳性和有效性停止边界

Xinling Xu1, Atsuki Hashimoto2, Belay B Yimer2

  • 1Quantitative Science and Evidence Generation, Astellas Pharma Global Development Inc, Northbrook, Illinois, USA.

Journal of biopharmaceutical statistics
|September 17, 2025
PubMed
概括

对于II期瘤学试验的新贝叶斯最佳设计,BOP2-FE,允许早期停止有效性或徒劳性. 这种灵活的设计可以控制I型错误,最大限度地提高功率,减少样本大小,同时保持患者安全.

关键词:
贝叶斯适应式设计是贝叶斯的适应式设计.在早期停止停止.有效性 有效性 有效性.虚无的虚无的虚无的去/不去的决定.一个单臂试验试验.

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