在塔克罗利斯治疗期间发展的慢性炎症性脱叶林性多基基隆性神经病 (CIDP):一系列病例
Matthew C Evans1, Roberto Bellanti2, Samer Dahdaleh1
1Imperial College Healthcare NHS Trust, London, UK.
Muscle & nerve
|September 17, 2025
概括
慢性炎症性消毒性多基基隆性神经病变 (CIDP) 可能发生在接受TACROLIMUS治疗的器官移植患者中. 静脉注射免疫球蛋白 (IVIg) 经常改善症状,并且切换免疫抑制剂有助于管理病情.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 塔克罗利马斯是固体器官移植后的重要免疫抑制剂.
- 慢性炎症性脱叶林化多基隆性神经病变 (CIDP) 是一种罕见但严重的神经并发症.
- 塔克罗利斯和CIDP之间的关联并未得到广泛认可.
研究的目的:
- 为了描述CIDP的临床特征,用塔克罗利斯治疗的患者.
- 为了研究TACROLIMUS诱导的CIDP的诊断特征和病程.
- 为了评估这个患者队列的治疗反应和结果.
主要方法:
- 六名被诊断患有CIDP的患者的回顾性病例系列.
- 患者在实体器官移植中接受了塔克罗利斯.
- 分析了诊断标准 (2021年EFNS/PNS) 和治疗反应.
主要成果:
- 在多种移植类型中,Tacrolimus注射后5个月至13年间发生了CIDP.
- 在6名患者中,有5名患者通过静脉注射免疫球蛋白 (IVIg) 显示出临床改善.
- 将免疫抑制转换为西罗或阿扎西奥普林导致四名患者的疾病缓解.
结论:
- 药物治疗可能与CIDP的发展有关,即使在长期使用后.
- IVIg是塔克罗利斯相关的CIDP的有效治疗方法.
- 替代性免疫抑制剂可以控制这种情况,允许停止使用塔克罗利斯.
更多相关视频
11:34A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
795
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.7K
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
493
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
493
Pulmonary Tuberculosis I
844
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
844
Nephrotic Syndrome I : Introduction
504
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
504
