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Updated: Jan 17, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

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破坏表观遗传联盟:针对DNMT1-UHRF1的结构见解和治疗策略

Emadeldin M Kamel1, Mohamed A M Ali2, Ahmed A Allam2

  • 1Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. emad.abdelhameed@science.bsu.edu.eg.

Functional & integrative genomics
|September 17, 2025
PubMed
概括

研究人员开发了针对DNMT1-UHRF1复合体的新型小分子和PROTACs,用于癌症治疗. 这些表观遗传药物破坏了DNA甲基化维护,在临床前模型中显示出与现有治疗相比毒性降低的前景.

关键词:
基础翻转抑制的抑制DNMT1UHRF1 的使用情况.表观遗传疗法是一种表观遗传疗法.维护DNA甲基化 维护DNA甲基化蛋白蛋白相互作用破坏者

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