与口腔口腔裂相关的多态和环境因素作为口腔癌风险潜在标志物
Adriana Mendonça da Silva1, Michelle Miranda Lopes Falcão1, Valéria Souza Freitas1
1Universidade Estadual de Feira de Santana -UEFS, Department of Health, Feira de Santana, BA, Brazil.
有口腔口腔裂的家族病史与口腔癌没有联系. 然而,居住地和特定的遗传变异 (rs1533767,rs3923087,rs11867417) 与口腔潜在恶性疾病和口腔癌有关.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 环境健康 环境健康
背景情况:
- 口腔口腔裂和口腔癌具有潜在的病因联系.
- 环境因素可能会影响共享生物通路中的基因表达.
研究的目的:
- 调查口腔口腔裂与口腔潜在恶性疾病 (OPMD) 或口腔状细胞癌 (OSCC) 之间的关联.
- 在这种关联中,专注于遗传变异和环境风险因素.
主要方法:
- 病例控制研究,包括48例OPMD/OSCC病例和96例对照.
- 对WNT11 (rs1533767),GSK3B (rs9879992) 和AXIN2 (rs3923087,rs11867417) 变种进行基因造型.
- 采访收集了关于家族病史,生物和环境风险因素的数据.
主要成果:
- 在口腔裂家族史和OPMD/OSCC (p=0.52) 之间没有发现显著的关联.
- 居住地显示出一个显著的关联 (调整后OR:5.46,p<0.001).
- 遗传变异rs1533767 (OR:1.94,p=0.042),rs3923087 (OR:0.58,p=0.038) 和rs11867417 (OR:0.51,p=0.010) 与OPMD/OSCC有关,这些变异与OPMD/OSCC有关.
结论:
- 特定的环境因素,如居住地,与OPMD/OSCC风险有关.
- 某些遗传变异 (WNT11,AXIN2) 可能会影响对OPMD/OSCC的易感性.
- 研究结果表明,口腔癌病因学中环境和遗传学的复杂相互作用.
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