在有炎症性肠病的门诊患者中,口腔粘膜的发现
Lilly Esquivel-Pedraza1, Laura Fernández-Cuevas2, Isianel Delgado-Martínez3
1Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Department of Dermatology, Mexico City, Mexico.
Brazilian oral research
|September 17, 2025
概括
所有患有性结肠炎 (UC) 和克罗恩病 (CD) 的患者都经历了口腔病变 (OL). 45岁以上的年龄,低血红蛋白和口水使用与这些炎症性肠病患者的OL风险增加有关.
科学领域:
- 胃肠病学 胃肠病学
- 口腔医学是指口腔医学.
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),影响着大量患者群体.
- 口腔粘膜病变 (OL) 是系统性健康状况的潜在指标,包括IBD.
- 了解IBD患者的OL患病率和风险因素对于全面的患者护理至关重要.
研究的目的:
- 确定诊断为性结肠炎 (UC) 和克罗恩病 (CD) 的患者口腔粘膜病变 (OL) 的频率.
- 分析OL存在与IBD患者的各种临床和实验室参数之间的关系.
- 确定与口腔粘膜病变发生相关的预测因素,在患有炎症性肠病的个体.
主要方法:
- 采用了横截面研究设计,包括从90名IBD患者收集流行病学,临床和实验室数据.
- 统计分析包括单变量和多变量方法来评估变量之间的关系.
- 患者根据IBD类型 (UC或CD),疾病活性,年龄和实验室发现进行分类.
主要成果:
- 所有参与的患者 (100%) 均表现出口腔粘膜病变 (OL),舌头裂是最常见的发现 (75.6%).
- 与CD患者相比,UC患者的毛舌明显更常见 (p=0.03).
- 预测OL的预测因素包括45岁以上的年龄,较低的血红蛋白水平 (与粘膜白相关),以及口腔冲洗的使用 (与黑色素相关).
- 45岁以上的患者患水,白血湿,角膜炎,舌裂和传染过程的风险明显更高.
- 观察到舌头裂与 кандидоз风险增加之间存在显著的关联 (p=0.007).
结论:
- 口腔粘膜病变 (OL) 在性结肠炎 (UC) 和克罗恩病 (CD) 患者中非常普遍.
- 诸如老年 (>45岁),低血红蛋白水平和口水的使用等因素是IBD患者OL的重要预测因素.
- 在治疗炎症性肠病 (IBD) 患者时,应强调例行口腔检查和早期检测OL.
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