2025年加拿大的AMR优先病原体:基于证据的排名和公共卫生影响
Kahina Abdesselam1, Raymond-Jonas Ngendabanka1, Pia K Muchaal1
1Antimicrobial Resistant Task Force, Public Health Agency of Canada, Ottawa, Ontario, Canada.
PloS one
|September 17, 2025
概括
加拿大更新了其抗菌素耐药性 (AMR) 病原体清单,以确定优先威胁. 耐卡巴胺的肠道细菌和白菌是最大的风险,需要有针对性的监测和干预措施.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球健康挑战,影响医疗保健.
- 加拿大最初的AMR病原体清单 (2015) 需要更新,因为耐药性模式的演变和加强的监测.
- 加拿大抗菌素耐药性监测系统 (CARSS) 提供了基础数据.
研究的目的:
- 系统地更新加拿大的AMR病原体优先级,使用国家数据.
- 识别最紧迫的抗菌素耐药性威胁,为监测和公共卫生战略提供信息.
- 将健康公平纳入反抗药物耐药性风险评估框架.
主要方法:
- 一项多标准决策分析 (MCDA) 使用加拿大数据 (2017-2022) 评估了155种潜在的AMR病原体.
- 基于风险的病原体排名使用了包括健康公平在内的9个标准.
- 专家共识提供了标准权重,敏感性分析确保了稳定性.
主要成果:
- 29种AMR病原体被确定为具有重大风险的病原体,分为四个层次.
- 一级病原体 (例如,耐卡巴尼姆的肠道细菌,黄菌) 构成了对公众健康的最高风险.
- 优先考虑突出了对性传播感染 (STIs) 的担忧,如耐药尼塞利亚淋病和耐药Shigella spp.
结论:
- 更新的优先顺序为加拿大抗菌耐药性监测和应对提供了一个公平信息的框架.
- 识别高影响性病原体和关键监测区域,以采取有针对性的公共卫生行动.
- 为指导研究,创新和感染预防工作提供战略工具.
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