协调的海马-内腔表达支持人类依赖于环境的空间导航
Pengcheng Lv1,2, Dong Chen1,2, Chao Zhang3
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
PLoS biology
|September 17, 2025
概括
海马和脑内皮层的神经振荡在导航过程中追踪上下文和对象信息. 低频脑波 (2-8 Hz) 在这些区域之间同步,改善空间导航性能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 目标导向的行为需要整合上下文和对象信息.
- 人类在空间导航中进行上下文处理的神经机制尚未得到充分理解.
- 海马和脑内皮层对于空间记忆和导航至关重要.
研究的目的:
- 在空间导航过程中调查上下文和对象表示的神经基础.
- 为了探索神经振荡在海马-内腔内脉电路中的作用.
- 在空间导航任务中将神经活动模式与行为表现联系起来.
主要方法:
- 在31名患者身上记录了内脑电图 (iEEG).
- 患者执行了取决于上下文的空间导航任务.
- 分析的重点是海马体 (HC) 和脑内皮层 (EC) 中的振荡模式.
主要成果:
- 在HC和EC中,不同的振荡模式分别代表了上下文和对象信息.
- 神经表征的共变性预测了行为表现.
- 低频振荡 (2-8 Hz) 在两种表示中都占主导地位.
- 通过同步HC和EC之间的低频振荡,在EC中增强了对象表示.
结论:
- 低频神经动力学对于在海马-内腔回路中表示上下文和对象信息至关重要.
- 低频振荡的区域间同步支持上下文依赖的空间导航.
- 这些发现阐明了复杂的导航行为背后的神经机制.
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