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Updated: Jan 17, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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与蛋白质向蛋白质扩散结合的配体作为蛋白质-蛋白质相互作用的抑制剂

William Jeffries1, Bryan M Delfing1, Xavier E Laracuente1

  • 1School of Systems Biology, George Mason University, Manassas, Virginia, United States of America.

PLoS computational biology
|September 17, 2025
PubMed
概括

两种抑制剂,DP9和DP9o,研究了它们阻止委内瑞拉马类脑炎病毒 (VEEV) 核定位信号 (NLS) 与importin-α结合的能力. 通过破坏NLS-importin-α相互作用,DP9被证明更有效,提供了一个潜在的治疗策略.

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