臭氧自动血疗对炎症反应和术后认知功能的影响,在接受心肺旁路切换置换的患者中
Wenyong Peng1, Yulong Du2, Wei Lu3
1Zhejiang University School of Medicine Affiliated Jinhua Hospital Department of Anesthesiology Jinhua Zhejiang People's Republic of China Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, People's Republic of China.
Brazilian journal of cardiovascular surgery
|September 17, 2025
概括
臭氧自血疗法 (O3-AHT) 改善了大脑的氧化代谢,并在心脏置换手术后减少了炎症和认知功能障碍. 这种疗法为接受心肺旁路术的患者提供了潜在的益处.
科学领域:
- 心血管外科心血管外科
- 神经外科 神经外科
- 免疫学 免疫学 免疫学
背景情况:
- 在门置换手术期间,心肺旁路 (CPB) 可以引发炎症反应并影响认知功能.
- 手术后认知功能障碍 (POCD) 对接受心脏手术的患者来说是一个重大问题.
- 臭氧自血疗法 (O3-AHT) 是一种具有潜在抗炎作用的替代疗法.
研究的目的:
- 研究O3-AHT对炎症标志物和CPB进行门置换的患者的认知结果的影响.
- 在这个患者群体中,将O3-AHT与标准治疗 (储存输血) 的效果进行比较.
主要方法:
- 一项涉及130名用CPB进行门置换的患者的研究,分为O3-AHT和对照组.
- 监测血液气体,氧和和大脑氧气提取率.
- 使用ELISA测量炎症性细胞因子 (IL-6,TNF-α,IL-1β) 和脑损伤的生物标志物 (S100β,NSE).
- 使用迷你精神状态检查和蒙特利尔认知评估尺度评估认知功能.
主要成果:
- O3-AHT组显示了手术期间大脑氧化代谢的改善.
- 在O3-AHT组24小时后,IL-6,TNF-α,IL-1β,S100β和NSE的术后水平显著降低.
- 在接受O3-AHT的患者中,认知功能障碍得到缓解.
- 两组之间没有观察到输血并发症发生率的显著差异.
结论:
- O3-AHT增强了手术内大脑氧化代谢在接受CPB门置换的患者.
- O3-AHT有效地减少了24小时的术后炎症反应.
- 在这个患者队列中,O3-AHT的应用减轻了术后认知功能障碍.
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