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来自Lagerstroemia indica L. 树皮的三烯具有抗ZIKV活性

Yuan-Lin Kong¹, Wen-Cong Gao², Xiao-Huan Zhou²

¹Key Laboratory of Medicinal Chemistry For Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Co. Ltd. Yunnan Research & Development Center For Natural Products, School of Chemical Science and Technology, School of Pharmacy, and School of Life Sciences, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.

Chemistry & biodiversity

|September 17, 2025

概括

来自Lagerstroemia indica树皮的两种新型三烯显示出对寨卡病毒 (ZIKV) 的潜力. 化合物4有效抑制ZIKV包膜蛋白表达和病毒复制.

科学领域:

自然产品化学化学
病毒学病毒学
药用化学医学化学

背景情况:

拉格斯特罗米亚标志性L.树皮是生物活性化合物的来源.
三聚是一种具有多种生物活性的自然产品.
寨卡病毒 (ZIKV) 构成了严重的全球健康威胁.

研究的目的:

从Lagerstroemia indica L. bark中分离和描述化学成分.
为了评估隔离化合物的抗ZIKV活性.
研究活性化合物对ZIKV的作用机制.

主要方法:

使用色谱技术分离化合物.
通过NMR,HR-ESI-MS,UV和IR光谱学来阐明结构.
使用ECD计算确定绝对配置.
在体外抗ZIKV测定以确定EC50值.
西方斑点分析以评估病毒蛋白质表达.

主要成果:

两种新型三烯 (1-2) 和19种已知的三烯 (3-21) 被分离出来.
化合物4表现出强大的抗ZIKV活性,EC50为6.05±0.51μM.
化合物4抑制了ZIKV包裹 (E) 蛋白质表达和病毒复制以剂量依赖的方式.

结论:

拉格斯特罗米亚 indica L. 树皮含有具有显著抗ZIKV特性的化合物.
化合物4是ZIKV疗法的发展的一个有希望的头.
需要进一步的研究来探索化合物4的治疗潜力.

关键词:

Lagerstroemia indica L. 树皮皮的树皮是一种有机物.抗寨卡病毒 (ZIKV) 活动.三烯是一种三烯.

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