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医学成像和儿科和青少年血液癌症风险
Rebecca Smith-Bindman1,2,3, Susan A Alber4, Marilyn L Kwan5
1Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco.
The New England journal of medicine
|September 17, 2025
概括
儿童和青少年的医学成像辐射暴露与血液癌症风险的小但显著增加有关. 这一发现支持了关于儿科成像使用和安全性的知情决策.
科学领域:
- 儿科瘤学 儿科瘤学
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 从儿童的医学成像中评估辐射诱导的血液癌症风险对于明智的决策至关重要.
- 医学成像是儿童群体辐射暴露的重要来源.
研究的目的:
- 评估医学成像辐射暴露与儿童和青少年血液癌症风险之间的关联.
- 量化由于医学成像辐射引起的血液癌症的过度风险和可归因比例.
主要方法:
- 对超过370万儿童和青少年进行了一项回顾性队列研究.
- 量化了从医学成像中到活跃骨髓的辐射剂量.
- 连续时间危险模型被用来估计累积辐射暴露与血液癌症风险之间的关联.
主要成果:
- 随着累积辐射剂量的增加,观察到血液癌症风险的显著增加.
- 血液癌症的相对风险为1.76暴露30mGy与没有暴露相比.
- 据估计,该队列中大约10.1%的血液癌症可能归因于医学成像中的辐射暴露.
结论:
- 暴露于医学成像辐射与儿童和青少年血液癌症风险的小但显著增加有关.
- 像CT扫描这样的高剂量成像程序与更大的风险有关.
- 这些发现强调了在儿科医学成像中优化辐射剂量的重要性.
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