相关实验视频

Updated: Jan 17, 2026

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

整合网络药理学和实验验证,解读伊卡林对丸衰老的保护作用

Jiandong Sun¹, Chengyu Lv², Zihang Lin³

¹Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou 350122, PR China; Department of Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, PR China; Department of Andrology, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350122, PR China; Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, Fuzhou 350122, PR China.

Ecotoxicology and environmental safety

|September 17, 2025

概括

伊卡林 (ICA) 通过减少氧化应激和激活ESR1/AKT通路来对抗男性生殖衰老. 这种天然化合物恢复的合成,并减轻丸老化的细胞衰老.

科学领域:

生殖生物学生殖生物学
老年学是一门学科.
药理学药理学是指药理学的学科.

背景情况:

男性的生殖衰老的特点是丸中反应性氧物种 (ROS) 的增加,导致丸激素降低和精子生成受损.
伊卡林 (ICA) 是传统中医药中的生物活性单体,在保护ROS和DEHP等环境有毒物质方面表现有前途.

研究的目的:

研究伊卡林对男性生殖老化的治疗作用.
在老年小鼠模型中阐明依卡林保护作用背后的分子机制.

主要方法:

综合网络药理学,分子对接和分子动力学模拟被用于识别icariin的目标.
在体内实验中,使用老年小鼠通过口腔食治疗伊卡林.

主要成果:

在丸衰老中确定了125个潜在的伊卡林标,这些标与ROS清理,脂质代谢,雄激素合成,铁亡以及PI3K/AKT信号传递有关.
分子对接和模拟证实了伊卡林与关键标 (ESR1,TP53,BCL2,HIF1A,TNF) 之间的高结合潜力.
在体内,伊卡林降低了ROS,甲和Fe2+水平,激活了ESR1/AKT通路,恢复了的合成,并减轻了老化丸的衰老.

结论:

伊卡林在改善男性丸衰老方面显示出显著的治疗潜力.
这项研究为icariin在通过ESR1/AKT通路对抗生殖衰老中的作用提供了机制基础.

关键词:

伊卡里恩是什么意思分子对接是分子对接.分子动力学模拟模型网络药理学网络药理学丸的衰老丸的衰老

更多相关视频

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

相关概念视频

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...