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来自肠道微生物群的醇硫酸盐在慢性病中促进心力衰竭

Yun Zhang¹, Xuejie Han², Tao Feng¹

¹Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.

Cell host & microbe

|September 17, 2025

概括

来自肠道细菌的硫酸会在慢性病中加剧心力衰竭. 益生菌治疗减少了这种代谢物,改善了心脏功能,并为心力衰竭提供了新的诊断方法.

科学领域:

微生物学微生物学
腎臟病學 (nephrology) 是一種醫學.
心脏病学心脏病学

背景情况:

心力衰竭 (HF) 在慢性病 (CKD) 中很常见,但它们之间的联系机制尚不清楚.
肠道微生物群的改变与CKD相关的HF有关,使诊断和治疗复杂化.
有助于这种联系的特定微生物代谢物需要识别.

研究的目的:

为了确定关键的肠道微生物代谢物参与CKD相关的HF.
阐明这些代谢物影响心脏功能的机制.
探索针对微生物群的干预措施和诊断策略,用于CKD相关的HF.

主要方法:

由大肠杆菌通过三甲酶 (TnaA) 途径产生的已识别的氧硫酸盐 (IS).
使用AHR-CYP1B1轴研究了IS对心脏线粒体和亡的影响.
在老鼠和CKD患者模型中,服用益生菌来降低大肠杆菌和IS水平.
进行了前性队列研究,以评估大肠杆菌的丰富性,以预测HF.

主要成果:

核糖硫酸盐 (IS) 被确定为关键代谢物,将CKD与HF联系起来.
IS破坏心脏线粒体功能,并诱导心肌细胞亡.
益生菌干预减少了大肠杆菌和IS,改善了老鼠和CKD患者的心脏结果.
大肠杆菌的丰富性表明,在6个月内预测HF发病的潜力.

结论:

肠道微生物群-IS轴在CKD相关的高频率中发挥着关键作用.
准肠道微生物群,特别是大肠杆菌,为CKD-HF提供了一个治疗策略.
大肠杆菌的丰富性作为一个潜在的早期诊断生物标志物为HF在CKD患者.

关键词:

埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.慢性脏疾病慢性脏疾病心脏衰竭是因为心脏衰竭.硫酸印氧基硫酸盐的使用方法

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