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口服的Salvia officinalis基消除死亡率,并减轻急性TNBS小鼠结肠炎的炎症

Rosa Direito¹, João Rocha¹, Inês Alves de Melo²

¹Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal.

|September 17, 2025

概括

在大肠炎的小鼠模型中,提取物显著降低了炎症和死亡率. 这项研究突出了Salvia officinalis的潜力,作为一种用于炎症性肠病 (IBD) 的新疗法.

科学领域:

药理学药理学是指药理学的学科.
胃肠病学胃肠病学
自然产品自然产品

背景情况:

炎症性肠病 (IBD) 涉及氧化应激,上调iNOS和COX-2.
在结肠炎模型中,Salvia officinalis 类的抗炎作用仍然未被评估.
这项研究在TNBS诱导的小鼠结肠炎模型中研究了一种Salvia officinalis基提取物.

研究的目的:

为了评估Salvia officinalis基提取物在TNBS大肠炎小鼠模型中的有效性.
评估提取物对炎症标志物,疾病活动和死亡率的影响.
探索果的潜力作为IBD的治疗方法.

主要方法:

制备了一种水性乙醇Salvia officinalis叶片提取物,并对其含量进行了标准化.
小鼠接受了肠内TNBS,然后口服载体或提取物.
评估了疾病活动,结肠长度,组织学,iNOS/COX-2表达和生存时间.

主要成果:

圣提取物显著减少了腹,和结肠缩短.
死亡率从36%降至0%,组织学得分有所改善.
iNOS和COX-2的过度表达正常化,证实了抗炎活性.

结论:

口服圣提取物证明了对急性TNBS大肠炎的保护.
提取物使关键炎症标志物正常化,并消除了与手术相关的死亡率.
圣类醇代表了IBD治疗的有前途的多目标线索,需要进一步调查.

关键词:

在COX-2中,COX-2是最常见的.大肠炎是什么意思 IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD 核武器的扩散罗斯马林酸是一种酸.我们的 iNOS iNOS

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