印度尔疗法:最新的FDA更新,正在进行的试验和未来的方向
Noor-Ul-Huda Butt1, Sultan Nacak Baytas2
1Department of Material Science and Engineering, Faculty of Engineering, Monash University, 3168 Melbourne, Australia.
Drug discovery today
|September 17, 2025
概括
印醇化合物表现出多样化的治疗潜力,从细胞毒性演变为向药物. 这篇评论分析了他们在过去十年中FDA批准,撤回和研究药物的旅程.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 在各种治疗领域,包括瘤学,病毒学,神经学和代谢障碍中,Indole支架是关键的药剂.
- 在过去的十年中,基于醇的药物的临床场景经历了显著的演变,受到监管行动和COVID-19流行病等新出现的健康挑战的影响.
研究的目的:
- 系统地审查FDA批准的,撤回的和在研究中的过去十年的含有醇的药物.
- 分析不断变化的临床结果,监管趋势,以及基于醇的药物的治疗重新定位.
- 为未来的开发和优化用于多目标治疗的室内支架提供框架.
主要方法:
- 系统的文献审查含有英多尔的药物.
- 对FDA批准,撤销和临床试验数据的分析.
- 药理类,结构特征和治疗结果的评估.
主要成果:
- 已观察到从细胞毒性转向向性抗癌道剂的转变.
- 基于Indole的抗病毒药物已经获得了突出地位,特别是在应对COVID-19大流行时.
- 越来越多的兴趣在神经活性,包括迷幻化合物,与进步在表观遗传和代谢调节器. 印度基抗生素的代表性较低.
结论:
- 印多尔支架在药物开发中表现出了显著的多功能性和适应性.
- 未来的研究应该专注于优化内部结构以提高效率,并探索多目标应用.
- 基于醇的药物的战略开发对于解决各种治疗领域未满足的医疗需求至关重要.
相关概念视频
01:11Clinical Trials: Overview
4.6K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.6K
01:16Clinical Trials
10.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.2K
01:26FDA Approved Drugs: Changes to Approved Drugs
245
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
245
01:26Drug Administration and Therapy Phases: Overview
1.3K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.3K
01:28Preclinical Development: Overview
5.8K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.8K
01:25Drug Regulation
2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K