在2型糖尿病患者中,食酸负荷和肉症之间的关联
Shinta Yamamoto1, Yoshitaka Hashimoto2, Fuyuko Takahashi1
1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Clinical nutrition ESPEN
|September 17, 2025
概括
饮食中较高的酸含量与老年2型糖尿病患者 (T2DM) 的肌肉消耗状况 - - 肉症有关. 这项研究发现,饮食中增加的酸性负荷与这一群体的较低肌肉质量和力量有关.
科学领域:
- 老年学是指老年学的学科.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 肉症是2型糖尿病 (T2DM) 的常见并发症,影响移动性和生活质量.
- 饮食中的酸性负载与代谢障碍有关,但其在T2DM相关的肉症中的具体作用尚不清楚.
研究的目的:
- 调查与T2DM诊断的老年人中饮食酸荷载和肉症之间的关联.
- 确定潜在酸负载 (PRAL) 和内源性净酸产量 (NEAP) 等指标是否与肉症指标相关.
主要方法:
- 对298名患有T2DM的60岁以上成年人进行横截面研究.
- 通过手握强度和骨肌肉质量指数 (生物电阻分析) 评估的萨尔科佩尼亚.
- 使用PRAL和NEAP量化的食酸负载;用多变量回归分析的关联.
主要成果:
- 在13.1%的参与者中,肉症存在.
- 较高的PRAL和NEAP显著与较低的骨肌肉质量指数相关.
- 更高的NEAP仍然与肌肉力量有显著的关联,更高的PRAL显示出类似的趋势.
- 升高的PRAL和NEAP水平与三倍增加的肉类的几率有关.
结论:
- 较高的食酸荷载与T2DM的老年人中沙尔科佩尼亚显著相关.
- 这些发现表明,饮食中的酸含量可能是影响肌肉健康的可修改因素.
- 针对酸载荷的饮食干预措施的进一步研究可能有助于在T2DM中治疗肉症.
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