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用剂治疗的儿童有助于听力损失的遗传多态:系统审查和元分析协议
Lara Chavaz1,2, Jakica Ćavar Pavić3,4, Isabelle Dupanloup5
1CANSEARCH Research Platform for Paediatric Oncology and Haematology, Department of Paediatrics, Gynecology and Obstetrics, University of Geneva Faculty of Medicine, Geneva, GE, Switzerland lara.chavaz@unige.ch.
BMJ open
|September 17, 2025
概括
这一元分析回顾了影响引起的听力损失 (PIHL) 的遗传因素在接受癌症治疗的儿童. 了解这些遗传联系可以帮助个性化治疗,并减少儿童癌症幸存者的听力损伤.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 听力学 听力学是指听力学.
背景情况:
- 基于的化疗 (cisplatin,carboplatin) 对儿科癌症至关重要,但会导致不可逆转的听力损失 (PIHL).
- 已知的PIHL风险因素并不能完全解释儿童个体易感性的原因.
- 遗传倾向被怀疑在儿童群体的PIHL发展中起着重要作用.
研究的目的:
- 在21岁以下的个体中系统地审查和元分析与PIHL相关的遗传多态性.
- 确定导致PIHL个体间变异的遗传因素.
- 为儿童癌症患者提供个性化治疗策略的信息.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括儿童群体PIHL的RCT,队列,病例控制和横截面研究.
- 使用固定和随机效应模型进行全面的数据库搜索 (PubMed,EMBASE,Cochrane) 和元分析.
主要成果:
- 该研究将通过森林地块展示与PIHL相关的遗传多态性发现.
- 后分析将量化鉴定出的遗传因素对PIHL风险的影响.
- 异质性,研究质量和偏差将使用I2指数和GRADE方法进行评估.
结论:
- 这一审查将澄清儿童PIHL的遗传贡献.
- 研究结果将为制定有针对性的策略提供基础,以减轻儿童癌症护理中的听力损失.
- 对遗传易感性的更好理解可以导致个性化的治疗方法.
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