在患有原发性Sjögren综合征的患者中,低频波动的频率依赖和时间变化
Chunfeng Hu1, Luoyu Wang1,2, Xiuhong Ge1
1Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.
Lupus science & medicine
|September 17, 2025
概括
低频波动的幅度 (ALFF) 显示了初级Sjögren患者的频率依赖性和时间性大脑变化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 主要Sjögren综合征 (pSS) 经常影响中枢神经系统,导致认知缺陷.
- 在pSS中这些神经症状背后的精确机制在很大程度上是未知的.
- 研究大脑功能改变对于理解PSS病理生理学至关重要.
研究的目的:
- 为了研究PSS患者低频波动 (ALFF) 幅度的变化.
- 确定这些ALFF变化是否表现出频率依赖性和时间变化.
- 探索导致PSS相关认知缺陷的潜在神经机制.
主要方法:
- 在68名pSS患者和69名健康对照中进行了休息状态功能性MRI和神经心理评估.
- 在慢-5 (0.01-0.027 Hz) 和慢-4 (0.027-0.073 Hz) 频段进行了ALFF分析.
- 动态ALFF (dALFF) 用于评估时间变化,并检查了与神经心理学数据的相关性.
主要成果:
- 在pSS患者的右状回环中观察到异常ALFF,跨子频段.
- 左前中心环和右中额头环显示ALFF增加,特别是在慢-5频段.
- dALFF揭示了左补充运动区域的异常活动,与特定大脑区域和认知尺度之间的相关性.
结论:
- ALFF指标为PSS中区域大脑功能变化提供了更深入的见解,证明了频率依赖和时间变化.
- 这些发现补充了传统的指标,并提高了对pSS中大脑功能的理解.
- ALFF显示出作为研究pSS患者神经机制的新工具的潜力.
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