患有SLE的患者的维生素D受体表达水平及其与维生素D状况,疾病过程和骨矿物质密度的关系
Sergii Shevchuk1, Tetiana Malovana2, Liubov Marynych1
1Department of Internal Medicine No. 2, National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
Lupus science & medicine
|September 17, 2025
概括
低维生素D受体 (VDR) 水平在全身性红斑狼 (SLE) 患者中很常见,与疾病活性和维生素D状况有关,但与骨密度无关.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种具有复杂病源性的慢性自身免疫性疾病.
- 维生素D受体 (VDR) 在免疫调节和平衡中起着至关重要的作用.
- 在SLE患者中的VDR状态及其与疾病参数的相关性需要进一步调查.
研究的目的:
- 在SLE患者中量化血清维生素D受体 (VDR) 度.
- 评估VDR水平与维生素D状态,疾病活性和骨代谢标记物的相关性.
- 评估SLE中VDR水平和骨矿物质密度 (BMD) 之间的关系.
主要方法:
- 一项涉及99名SLE患者和30名健康对照者的横截面研究.
- 测量血清VDR,维生素D,C反应蛋白 (CRP),IN-6 (IL-6),骨质卡尔辛 (OC),I型原蛋白的C端端端 (CTX) 和红细胞沉积率 (ESR).
- 双能X射线吸收计 (DXA) 用于骨矿物质密度 (BMD) 的评估.
主要成果:
- 与对照组 (23.12 ng/mL) 相比,SLE患者的平均VDR水平显著降低 (12.78 ng/mL).
- 在77.8%的SLE患者中观察到低VDR度,与年龄和较高的疾病活性相关 (CRP升高,IL-6).
- 低VDR水平与维生素D状况降低和CTX度增加有关,但与骨质量,性别,疾病持续时间,BMI或狼性炎无关.
结论:
- 低VDR度在SLE患者中普遍存在,与疾病活性和维生素D缺乏有关.
- VDR水平与骨循环标记 (CTX) 有关,但与该队列的骨矿物质密度没有直接关系.
- 这些发现强调了评估VDR状态在SLE管理中的重要性,特别是关于疾病活性和维生素D充足度.
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