韩国人口中饮食中的肌酸摄入量和心理健康
Sergej M Ostojic1,2,3, Sonja Baltic2, Dragana Zanini2
1Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway.
Nutritional neuroscience
|September 17, 2025
概括
饮食中摄入较高的肌酸可以提供对抑郁和焦虑的保护作用. 这项研究发现,在摄取较多肌酸的人群中,抑郁症得分较低,自杀念头减少.
科学领域:
- 营养精神病学 营养精神病学
- 心理健康研究 心理健康研究
- 流行病学 流行病学
背景情况:
- 现有研究表明,饮食中的肌酸对抑郁和认知有好处.
- 之前的研究没有评估美国以外的人口的心理健康状况,也没有包括青少年.
- 肌酸在整体精神健康中的作用需要进一步研究.
研究的目的:
- 调查每日肌酸消耗与心理健康指标之间的关联.
- 在韩国成年人群中检查与肌酸摄入有关的抑郁,焦虑和自杀倾向.
- 解决美国以外的不同年龄组关于肌酸和心理健康的研究差距.
主要方法:
- 采用2022年韩国国家健康和营养检查调查 (KNHANES) 数据的横截面研究.
- 分析包括5,257名参与者,他们的饮食摄入量和心理健康评估数据.
- 统计分析包括单向ANOVA和后勤回归,控制相关的共变量.
主要成果:
- 在肌酸摄入四分位数 (p=0.007) 中观察到抑郁症得分的显著差异.
- 最低摄入肌酸的四分位数表现出更高的抑郁症患病率和更高的自杀想法/尝试率 (p≤0.05).
- 较高的肌酸摄入量与普遍焦虑障碍的几率较低有关,尽管包括生活方式因素后,这并不显著.
结论:
- 饮食中摄入较高的肌酸可能与对抑郁症和自杀倾向的适度保护作用有关.
- 这些发现表明,肌酸消费与改善心理健康结果之间存在潜在联系.
- 由于横截面设计,无法确定因果关系;建议进行纵向和干预研究.
相关概念视频
Chronic Kidney Disease III: Interprofessional Care
344
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
344
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
184
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
184
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
190
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
190
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
238
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
238
Stress and Mental Health
810
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
810
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
560
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
560


