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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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相关实验视频

Updated: Jan 17, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

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优化免疫细胞中的线粒体功能:对癌症免疫疗法的影响

Huiyu Li1, Wenyi Jin2, Junhong Liu3

  • 1Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong.

Trends in cancer
|September 17, 2025
PubMed
概括

瘤微环境通过破坏线粒体功能来损害免疫细胞,导致免疫抑制. 恢复线粒体健康是增强抗瘤免疫力和采用细胞疗法的关键.

关键词:
这就是ROSOS ROS.嵌合式抗原受体 (CAR) 是一种代谢 代谢 代谢 代谢线粒体中的线粒体.瘤免疫疗法 免疫疗法

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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
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Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
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科学领域:

  • 免疫学 免疫学 免疫学
  • 代谢途径 代谢途径
  • 癌症生物学 癌症生物学

背景情况:

  • 瘤微环境 (TME) 为免疫细胞创造了代谢挑战.
  • 线粒体功能障碍是TME介导免疫抑制的一个重要因素.
  • 线粒体代谢在TME内的免疫细胞功能中的作用尚未完全理解.

研究的目的:

  • 审查TME压力因素如何影响线粒体动态和免疫细胞中的功能.
  • 探索线粒体功能障碍对T细胞,NK细胞和巨细胞抗瘤活动的影响.
  • 为突出恢复线粒体适应癌症免疫疗法的潜力.

主要方法:

  • 文献综述综合了关于TME,免疫细胞代谢和线粒体功能的当前研究.
  • 分析缺氧,营养竞争和代谢副产品如何影响免疫细胞.
  • 检查线粒体动力学,氧化还原平衡和mtDNA信号传递.

主要成果:

  • 像低氧和营养缺乏等TME压力因素会破坏线粒体动力学,氧化还原平衡和免疫细胞中的mtDNA信号传递.
  • 这种干扰会损害T细胞,NK细胞和巨细胞的激活,分化和抗瘤功效.
  • 线粒体功能障碍直接导致TME的免疫抑制性.

结论:

  • 恢复免疫细胞中的线粒体健康是克服TME诱导的免疫抑制的关键策略.
  • 准TME代谢物和加强线粒体质量控制可以改善免疫细胞功能.
  • 优化线粒体健康为采用细胞疗法和TME重编程提供了一个有希望的治疗轴.