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一种可移动的长期植入软微纤维用于动态生物电子

Ruijie Xie1,2, Fei Han3, Qianhengyuan Yu1

  • 1Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, The Guangdong Provincial Key Laboratory of Robotics and Intelligent System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

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此摘要是机器生成的。

研究人员开发了一种灵活,可移动的纤维传感器, 这种创新设备可以准确地在现场记录神经信号,并对先进的人机接口进行最小侵入性植入.

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科学领域:

  • 生物电子
  • 神经科学
  • 生物材料

背景情况:

  • 长期植入生物电子对于神经系统评估和人机接口至关重要.
  • 目前的生物电子探针往往不移动,并可能引起显著的组织反应.

研究的目的:

  • 介绍一个新的柔软,可伸缩,可移动的纤维传感器用于先进的生物电子接口.
  • 证明NeuroWorm具有高质量,长期和最小侵入性的生物电气和生物机械监测能力.

主要方法:

  • 通过滚动二维生物电子设备开发了一种1D神经纤维传感器.
  • 嵌入式纵向分布的电极阵列用于多式传感.
  • 在生物组织中评估现场信号记录和可引导的进步.
  • 在老鼠肌肉植入模型中评估了长期稳定性和生物相容性.

主要成果:

  • 在现场成功记录了高质量的时空生物电信号.
  • 这种装置在大脑和肌肉组织中表现出可引导的进步.
  • 在老鼠中,稳定的生物电能监测持续了43周.
  • 即使在植入54周后,也观察到微不足道的纤维细胞封装.

结论:

  • 它代表生物电子技术的重大进步, 从不移动的探针转变为活跃的智能设备.
  • 这项技术可以对神经系统进行长期,最少的侵入性和移动性评估.
  • 该平台有望在神经监控和人机界面的未来应用.