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XRCC1-Arg399Gln多态和前列腺癌风险之间的关联:更新的元分析

Jiang Deng¹, Lihua Xu², Jun Zhou³

¹Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China. 15972096274@163.com.

|September 17, 2025

概括

XRCC1基因多态 (Arg399Gln) 与前列腺癌风险有关. 这次元分析发现了显著的关联,特别是在亚洲人群中,这表明它可能作为预后生物标志物.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

受到XRCC1基因多态性等遗传变异影响的DNA修复能力在癌症发展中至关重要.
缺陷的DNA修复与各种癌症有关,包括前列腺癌 (PCa).
之前关于XRCC1编码子399多态和PCa风险之间的关联的研究已经产生了不确定的结果.

研究的目的:

进行更新的元分析,以澄清XRCC1 Arg399Gln多态和前列腺癌风险之间的关联.
评估这种多形态的潜力作为PCa风险和预后的生物标志物.

主要方法:

在PubMed,EMBASE,Wanfang,CNKI和Web of Science数据库中进行了系统的文献搜索.
二十个病例控制研究包括5803个PCa病例和5470个对照被纳入了元分析.
使用Stata软件计算95%置信区间 (CI) 的原始赔率比率 (OR),以评估相关性.

主要成果:

分析显示,XRCC1 Arg399Gln多态性与前列腺癌风险增加之间存在显著的关联.
具体来说,在衰退模型下,多态性与亚洲人群中PCa的明显更高的患病率有关 (OR=1.255,95%CI=1.063-1.481).
观察到的异质性很低 (I2 <25%).

结论:

XRCC1 Arg399Gln 多态性是前列腺癌的潜在危险因素.
这种遗传变异可能成为预测前列腺癌预后的宝贵生物标志物.

关键词:

多态化多态化.前列腺癌 (PCa) 是一种癌症.XRCC1-Arg399Glnnn 在线观看

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