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Maxam-Gilbert Sequencing

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

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Updated: Jan 17, 2026

Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling

Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling

Published on: July 1, 2014

使用解构-重构策略对金素进行稳定同位素标记

Benjamin J H Uhlenbruck¹, Andrew McNally¹

¹Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.

Journal of the American Chemical Society

|September 17, 2025

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No abstract available in PubMed .

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