预后营养指数与美国乳腺癌之间的相关性 成年人:NHANES 2001-2018 年的时间
Zhiyuan Rong1, Jiangwei Liu1, Weilun Cheng1
1Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Nutrition and cancer
|September 18, 2025
概括
较低的预后营养指数 (PNI),衡量营养和免疫状况,与患乳腺癌的风险更高有关. 这一发现表明PNI可以帮助评估乳腺癌风险.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 乳腺癌的发展受到炎症和营养的影响.
- 预后营养指数 (PNI),结合血清白蛋白和淋巴细胞计数,反映了营养状况和免疫能力.
- 低PNI与包括乳腺癌在内的各种癌症的不良结果相关.
研究的目的:
- 综合分析预后营养指数 (PNI) 与乳腺癌发病率之间的关联.
- 评估PNI作为乳腺癌风险分层工具的潜力.
主要方法:
- 从NHANES (2001-2018) 中分析了18,709名参与者,使用加权多变量后勤回归.
- 评估PNI和乳腺癌风险之间的剂量反应关系,以连续和三角形模型为模型.
- 使用两阶段线性回归模型确定乳腺癌发病率的PNI值,并使用XGBoost机器学习进行验证.
主要成果:
- 发现PNI和乳腺癌风险之间存在显著的反向关联;PNI每增加1个单位,风险降低4%.
- 较高的PNI水平与显著降低乳腺癌风险相关 (OR=0.58).
- 乳腺癌发病率的PNI值为58.0被确定,PNI是XGBoost模型中的顶级预测因素.
结论:
- 较低的PNI水平与乳腺癌风险增加有显著关联.
- PNI显示出作为乳腺癌风险分层的辅助指标的潜力.
- 需要进一步的前性研究来验证PNI的临床效用.
更多相关视频
相关概念视频
Cancer Prevention
7.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.7K
Cancer Survival Analysis
650
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
650
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
644
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
644
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Anorexia Nervosa
1.0K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
1.0K


