肺癌手握强度的预后价值:来自多中心前性队列研究的发现
Xin Wang1,2,3,4, Hong Zhao1,2,3, Lu Liang5
1Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Cancer control : journal of the Moffitt Cancer Center
|September 18, 2025
概括
手握强度 (HGS) 独立预测肺癌患者的生存率. 将HGS与血液检测结果结合起来可以提高预后准确度,提供个性化治疗和营养支持的工具.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 临床营养学 临床营养学
背景情况:
- 手握强度 (HGS) 是骨肌功能的一个关键指标.
- 它在肺癌中的预后价值需要进一步调查.
研究的目的:
- 评估HGS对肺癌患者整体存活期 (OS) 的预后意义.
- 开发一个综合HGS和血液学参数的预后模型.
主要方法:
- 前性队列研究 (INSCOC) 包括3604名肺癌患者.
- 考克斯的比例危险模型和nomogram开发用于OS预测.
- 使用ROC曲线和一致性指数 (C指数) 的评估.
主要成果:
- HGS与OS有显著的相关性;更高的HGS降低了死亡风险.
- 多变量分析确定了HGS,性别和血红蛋白作为保护因素.
- 血清葡萄糖和血小板数量升高是危险因素.
- 诺米图 (C指数=0.607) 的表现仅仅超过了HGS (C指数=0.541).
结论:
- HGS是肺癌生存的独立预测因素.
- 将HGS与血液学指标相结合,可以提高预后准确度.
- 诺米图为个性化预后和营养干预提供了一个实用的工具.
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