在儿科性综合征中增加动脉内心介质厚度:元分析
Yongzheng Zhang1, Mingda Song1, Hai Wang1
1The Second Department of Pediatrics, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Biomolecules & biomedicine
|September 18, 2025
概括
患有性综合征 (NS) 的儿童表现出动脉内心介质厚度 (cIMT) 的增加,表明早期动脉样硬化. 男性占主导地位和耐固醇NS可能会影响儿科患者的血管变化.
科学领域:
- 儿科脏病学 儿科脏病学
- 心血管健康 心血管健康
- 血管生物学 血管生物学
背景情况:
- 儿童的性综合征 (NS) 与动脉样硬化风险增加有关,由心动脉内膜介质厚度 (cIMT) 证明.
- 现有的关于NS和儿科cIMT的研究显示了不一致的发现,需要进一步调查.
- 早期发现儿科NS的血管变化对于长期健康管理至关重要.
研究的目的:
- 系统地比较儿童患者与NS和健康对照之间的cIMT测量.
- 确定导致cIMT研究结果在不同研究中的异质性的因素.
- 阐明NS和儿童亚临床动脉样硬化之间的关系.
主要方法:
- 进行了对13项观察病例控制研究的元分析.
- 来自578名NS儿童和741名对照儿童的数据使用随机效应模型进行了汇总.
- 在PubMed,Embase和Web of Science进行了搜索,截至2025年5月22日.
主要成果:
- 患有NS的儿童表现出明显高于对照组的cIMT (平均差异:0.06毫米;95%CI:0.04-0.08).
- 亚组分析显示,在男性参与者比例较高的研究中,cIMT差异更大.
- 根据年龄,疾病持续时间或BMI,血压或脂质的调整,没有发现cIMT的显著差异.
结论:
- 儿科性综合征与动脉内心介质厚度增加有关,这表明血管变化加速.
- 男性的比例和类固醇耐药性性综合征 (SRNS) 的患病率可能导致观察到的异质性.
- 这些发现强调了监测NS儿童心血管风险的重要性.
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