斋月期间的禁食与3种或更多抗高血糖药物PROFAST-3的2型糖尿病患者的活动变化和血糖外流有关
Mohammed Bashir1,2, Abdulaziz Al-Homaid3, Sabri Boughorbel2,3
1Endocrine Section, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
Qatar medical journal
|September 18, 2025
概括
在多种药物治疗的2型糖尿病 (T2D) 患者的斋月禁食没有显示出整体葡萄糖变化,但出现了长期的断食后高血糖症. 禁食期间的剧烈活动增加了低血糖的风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病管理 糖尿病管理
背景情况:
- 在斋月期间对2型糖尿病 (T2D) 患者的生理变化研究不足.
- 技术进步为禁食期间的T2D管理提供了新的见解.
- 专注于使用三种或更多抗糖尿病药物的T2D患者.
研究的目的:
- 为了研究斋月禁食对T2D患者血糖游行的影响.
- 评估斋月期间生命体征和身体活动的变化.
- 在多种药物治疗的T2D患者中分析葡萄糖概况,范围内的时间 (TIR),范围以上时间 (TAR) 和范围以下时间 (TBR).
主要方法:
- 哈马德总医院的前性观察研究.
- 包括服用三种或更多抗糖尿病药物的T2D患者.
- 使用快速血糖监测和Fitbit设备进行连续数据收集.
- 药物调整遵循国际斋月禁食指南.
主要成果:
- 在斋月之前和期间,TIR,TAR和TBR没有显著的整体变化.
- 门诊血糖概况显示,在禁食期间血糖降低,在伊法尔之前达到最低点,并在伊法尔后出现高血糖症.
- 身体活动在禁食期间减少,但在早餐前增加;强烈的活动与禁食期间降血糖风险增加有关.
结论:
- 在T2D患者中,斋月禁食并没有显著改变整体葡萄糖控制,但观察到伊法尔后高血糖症.
- 在禁食时间进行强烈的体力活动会带来低血糖的风险.
- 需要进一步的研究来了解生活方式对斋月禁食期间葡萄糖外游的影响.
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