人体阴道粘膜中的状细胞可以通过表达表面OX40L来指导CD4+T细胞的反应
HyeMee Joo1, Laurie Baert1, Agnes Yang1
1Department of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
Frontiers in immunology
|September 18, 2025
概括
在阴道树突细胞 (vDCs) 上的OX40L驱动Th2免疫反应,这对粘膜免疫至关重要. 阻断OX40L会减少Th2细胞,并影响IL-10和IL-21的产生,为阴道免疫提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 粘膜免疫力 粘膜免疫力
- 细胞免疫学 细胞免疫学
背景情况:
- 阴道粘膜 (VM) 免疫对于预防感染和癌症至关重要.
- 树突细胞 (DCs) 是关键的抗原呈现细胞,调节T细胞反应.
- 已知特定的VM DC子集,如朗格汉斯细胞 (vLC) 和CD1c+CD14-vDCs,可诱导Th2型CD4+T细胞反应,但机制尚不清楚.
研究的目的:
- 研究OX40L在VM树突细胞子集的Th2极化中的作用.
- 确定OX40L对由vLCs和CD1c+CD14-vDCs诱导的CD4+T细胞反应的影响.
主要方法:
- 在人体VM组织部分和特定的DC子集 (vLCs,CD1c+CD14-vDCs) 和巨细胞 (vMØs) 上使用流细胞计评估了OX40L表达.
- 使用抗OX40L抗体来中和OX40L的功能.
- 评估了OX40L中和对CD4+T细胞两极分化 (Th1与Th2),增殖和细胞因子产生 (IL-10,IL-21) 的影响.
主要成果:
- 无论是vLC还是CD1c+CD14-vDC都表达表面OX40L,与表达最小水平的vMØ不同.
- 中和OX40L显著降低了Th2型CD4+T细胞的频率和增殖,同时增加了IL-10+CD4+T细胞的反应.
- 抗OX40L治疗没有影响Th1型T细胞因这些DCs引起的反应.
- 还发现OX40L有助于通过vLCs和CD1c+CD14-vDCs诱导IL-21+CD4+T细胞.
结论:
- OX40L是阴道粘膜中由vLCs和CD1c+CD14-vDCs诱导的Th2两极化的关键调解者.
- OX40L影响IL-10+和IL-21+ CD4+ T细胞的频率,突出其在这个部位塑造适应性免疫力的作用.
- 这些发现为人类VM免疫学格局提供了新的见解,并建议OX40L作为免疫调节策略的潜在目标.
更多相关视频
12:32Isolation of Dendritic Cells from the Human Female Reproductive Tract for Phenotypical and Functional Studies
Published on: March 13, 2018
6.9K
08:11Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
9.1K
相关概念视频
T Cell Activation and Clonal Selection
14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Cytotoxic T Cells-mediated Immune Response
6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K
Immune Response Against Viral Pathogens
1.8K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Antigen Presenting Cells
3.0K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.0K
