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针对卵巢癌中瘤相关巨细胞的治疗方法的进步

Man Li¹, Yue Ma¹, Tinggeng Dai¹

¹Department of Gynecological Oncology, The First Hospital of Jilin University, Changchun, China.

Frontiers in immunology

|September 18, 2025

概括

与瘤相关的巨细胞 (TAMs) 通过促进转移和免疫逃避来驱动卵巢癌 (OC) 的进展和治疗耐药性. 了解TAM的起源和可塑性是开发有效的OC疗法的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
妇科瘤学妇科瘤学

背景情况:

卵巢癌 (OC) 是一种致命的妇科恶性瘤.
瘤微环境 (TME) 显著影响OC进展和治疗耐药性.
瘤相关巨细胞 (TAMs) 是OC TME中的关键免疫细胞,通常采用一种亲瘤M2表型.

研究的目的:

审查OC中TAMs的起源,异质性和功能性可塑性.
阐明TAMs在OC进展中的机械作用,包括转移,血管新生和免疫逃避.
通过外体信号传递和代谢重编程,突出显示TAMs对化学抵抗,特别是抗性的贡献.

主要方法:

在卵巢癌中对TAM进行临床前和临床研究的文献综述.
对TAM本体发生,表型和功能可塑性的分析.
检查TAM介导的OC病原和治疗耐药性的机制.

主要成果:

TAMs是OC进展的中心调解者,促进表皮细胞-介质细胞过渡 (EMT),血管生成和免疫逃避.
TAMs通过诸如外体信号传递和代谢重编程等机制,促进治疗耐药性,包括白金耐药性.
临床翻译的挑战包括目标毒性和对人类TAM起源的不完全理解.

结论:

TAMs是卵巢癌病原和治疗耐药性的关键参与者.
针对TAM是一个有前途的策略,可以改善OC治疗模式.
对TAM起源和可塑性的进一步研究对于有效的临床应用至关重要.

关键词:

在TAM中,极化是TAM.化学电阻是一种化学电阻.表皮细胞-介质细胞过渡.卵巢癌是发生在卵巢的癌症.瘤微环境是一个微环境.与瘤相关的巨细胞.

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