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降低相角作为轻度认知障碍的潜在指标

Mika Hasegawa^1,2, Hidenori Onishi², Yasutaka Mizukami²

¹Division of Nursing, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Journal of clinical biochemistry and nutrition

|September 18, 2025

概括

用生物电阻分析 (BIA) 测量的下腿相角 (PhA) 与老年人轻度认知障碍 (MCI) 有关. 这一发现表明PhA可能表明认知能力下降,并有助于痴呆症预防策略.

科学领域:

老年学是一门学科.
神经科学是一个神经科学.
生物医学工程生物医学工程

背景情况:

轻度认知障碍 (MCI) 是一个重大的公共卫生问题,往往是痴呆症的前身.
生物电阻分析 (BIA) 是一种评估身体成分的非侵入性方法.
阶段角 (PhA),来自BIA,反映了细胞完整性和细胞膜功能.

研究的目的:

调查相角 (PhA) 与轻度认知障碍 (MCI) 的存在之间的关联.
探索PhA作为认知衰退的生物标志物的潜力.

主要方法:

对290名社区居民 (平均年龄为74.9岁,83.7%为女性) 的横截面研究.
使用日本版本的蒙特利尔认知评估 (MoCA-J) 评估认知功能;MCI定义为MoCA-J得分≤25.
身体组成,包括腿部PhA,用BIA测量.
多重回归分析对混因素进行了调整.

主要成果:

在168名参与者中诊断出MCI.
与没有MCI的参与者相比,MCI的参与者表现出明显的下腿PhA (p=0.013).
腿部PhA在回归模型中显示出与MCI的显著关联 (β=0.103,p=0.015),调整后R2=0.50.

结论:

阶段角 (PhA) 可能作为轻度认知障碍 (MCI) 的潜在指标.
需要进一步的纵向和干预研究来验证PhA在痴呆症预防中的作用.
PhA可能是制定未来痴呆症预防策略的宝贵工具.

关键词:

生物电阻分析的生物电阻分析认知功能认知功能轻度的认知障碍轻度的认知障碍肌肉质量肌肉质量肌肉质量阶段角是相位的角度.

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