创伤后应激障碍和REM睡眠行为障碍:探索遗传关联和因果关系
Morvarid Ghamgosar Shahkhali1,2, Lang Liu1,2,3, Mohammad H Ghamgosar Shahkhali4
1The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
medRxiv : the preprint server for health sciences
|September 18, 2025
概括
创伤后应激障碍 (PTSD) 与神经退行相关的快速眼动睡眠行为障碍的风险增加有关. 然而,目前的基因分析并没有强烈支持因果关系,这表明需要进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
背景情况:
- 创伤后应激障碍 (PTSD) 是一种令人虚弱的心理健康状况.
- 孤立/异常性快速眼动睡眠行为障碍 (iRBD) 与神经退行性疾病有关.
- 创伤后应激障碍和iRBD之间的潜在遗传和因果关系仍未得到充分研究.
研究的目的:
- 调查PTSD和与神经退行相关的iRBD之间的遗传和因果关系.
- 通过使用多基因风险得分,遗传相关性和门德尔随机化来检查这种关系.
- 在iRBD患者中评估神经退行症标志物,包括患有和没有PTSD的患者.
主要方法:
- 使用全基因组关联研究 (GWAS) 总结统计数据和个体基因定型数据.
- 对与iRBD相关的PTSD进行了多基因风险评分 (PRS) 分析.
- 用多巴胺载体 (DAT) 成像来评估与没有PTSD的iRBD患者的神经退行症.
主要成果:
- 在PTSD多基因风险得分和iRBD (OR=1.15,p=0.005) 之间发现了显著的关联.
- 创伤后应激障碍和iRBD之间的遗传相关性很弱,而孟德尔随机化并不支持因果关系.
- 与没有PTSD的患者相比,iRBD患者的异常DAT成像结合状态显著更高 (p=0.01).
结论:
- 多基因风险评分分析表明,PTSD与神经退行相关的iRBD之间存在关联.
- 样本规模有限可能解释了遗传相关性较弱和缺乏因果关系证据.
- 为了阐明潜在的机制,对更大的队列进行进一步的研究是必不可少的.
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