南极冬季改变了人类无血细胞DNA的特性

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Updated: Jan 17, 2026

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Sergey Ponomarev¹, Anastasia Kotikova^1,2, Nikolay Osetsky¹

¹Laboratory of Immune System Physiology, Russian Federation State Research Center Institute of Biomedical Problems RAS (IMBP RAS), Moscow, Russia.

Biochemistry research international

|September 18, 2025

概括

南极冬季增加了亡,并改变了无细胞DNA (cfDNA) 的组成,以GC重复丰富它. 这种免疫系统的激活涉及在极端环境压力的最初几个月的炎症基因表达升高.

科学领域:

环境压力生理学生理学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

极端的环境条件,如南极冬季,可以引起生理压力.
血中的无细胞DNA (cfDNA) 可能反映出细胞亡和对压力的免疫反应.

研究的目的:

在南极冬季期间调查血液核酶活性 (NA) 和cfDNA特征的变化.
为了分析与亡相关的基因 (BAX,BCL2) 和免疫反应基因 (TLR9,AIM2,STING,RIG-I,NF-kB,IL-8,IL-17A) 对南极条件的反应的表达.

主要方法:

在南极冬季多个时间点收集了11名男性的血液样本.
检测包括血液核酶活性,cfDNA含量 (8-oxodG,rDNA,SatIII) 和所选基因的mRNA水平.

主要成果:

在冬季早期观察到亡率增加和BAX/BCL2RNA比率升高.
cfDNA显示GC丰富的rDNA增加,AT丰富的SatIII和8-oxodG减少.
免疫基因表达显示出不同的TLR9/AIM2反应,STING/RIG-I下调和显著的NFKB1,IL-8,IL-17A上调.

结论:

在南极冬季的前半段,亡显著过度活化.
cfDNA组成向GC重复转移,可能增强其生物活性.
炎症反应基因的表达增加表明免疫系统激活的增加.

关键词:

第三节时间:在TLR9中,没有细胞的DNA DNA.监禁的限制限制限制 rDNADNA 的意思是在冬季,冬天的冬天.

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