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棕色脂肪组织的成像:当前状态和未来的前景.

Junhao Li1, Li Wang2, Shiyao Wu2,3

  • 1Department of Radiology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China.

Theranostics
|September 18, 2025
PubMed
概括

棕色脂肪组织 (BAT) 成像面临的挑战与当前的方法,如[18F]FDG PET-CT. 新的成像技术为研究BAT提供精确的,具有成本效益的替代方案.

关键词:
棕色脂肪组织棕色脂肪组织功能 功能 功能 功能.影像成像技术 影像成像技术代谢 代谢 代谢 代谢 代谢生理学 生理学 生理学

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科学领域:

  • 代谢研究的研究.
  • 生物医学成像学 生物医学成像学
  • 热生成是一种热生成.

背景情况:

  • 棕色脂肪组织 (BAT) 是一种重要的代谢调节器,也是代谢障碍,心血管疾病和癌症的治疗点.
  • 目前黄金标准的BAT成像,即18F-flurodeoxyglucose正子发射断层扫描计算断层扫描 ([18F]FDG PET-CT),具有包括高成本,长扫描时间和辐射暴露在内的局限性.
  • 这些局限性阻碍了其在纵向研究中的使用和广泛的临床应用.

研究的目的:

  • 审查棕色脂肪组织 (BAT) 成像技术的当前进展.
  • 突出突出的新模式,克服[18F]FDG PET-CT.的局限性.
  • 讨论新型成像生物标志物的潜力和BAT成像的未来前景.

主要方法:

  • 关于BAT成像方法的综合文献综述.
  • 对BAT的替代生物标志物的分析,包括脂质含量, perfusion,密度,热排放和线粒体活性.
  • 讨论先进的成像技术,如正子发射断层扫描 (PET),单光子发射计算机断层扫描 (SPECT),磁共振成像 (MRI),计算机断层扫描 (CT),红外热学,光声成像和增强成像.

主要成果:

  • 几种先进的成像方法显示出精确,简单和广泛适用的BAT成像的前景.
  • 新兴的模式通过针对BAT的不同生理方面的方法,为[18F]FDG PET-CT提供了选择.
  • 这些技术旨在降低成本,缩短成像时间,并尽量减少辐射暴露.

结论:

  • 新型成像技术对于推进BAT研究及其治疗应用至关重要.
  • 未来的发展,包括人工智能集成,将进一步提高BAT成像的能力.
  • 改进的成像将促进对代谢和其他疾病的纵向研究和临床翻译.