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微RNA-124-3p调节NPY以影响抑郁症患者的食欲

Qianfa Yuan¹, Chunshui Yu², Jing Lu²

¹Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xiamen Xian Yue Hospital, Xian Yue Hospital Affiliated with Xiamen Medical College, Xiamen, 361000, Fujian, China.

Brain, behavior, & immunity - health

|September 18, 2025

概括

这项研究表明,microRNA-124-3p (miR-124-3p) 通过抑制神经Y (NPY) 抑制抑郁症的食欲. 准这种miR-124-3p/NPY通路可能有助于治疗严重抑郁症 (MDD) 中的食欲丧失.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
精神病学是一个精神病学.

背景情况:

在抑郁症中抑制食欲的机制尚未完全理解.
微RNAs (miRNAs) 涉及各种生物过程,包括神经系统疾病.
神经Y (NPY) 是食欲的关键调节剂.

研究的目的:

研究微RNA-124-3p (miR-124-3p) /神经Y (NPY) 轴在抑郁期间对食欲调节的作用.
探索潜在的治疗目标,以管理严重抑郁症 (MDD) 中的食欲功能障碍.

主要方法:

检查了MDD患者的血清miR-124-3p和NPY水平,并将它们与体重和食欲得分相关联.
利用慢性不可预测的轻度压力 (CUMS) 和脂聚糖 (LPS) 诱导的抑郁症小鼠模型来评估食物摄入量和体重.
在小鼠大脑组织中测量了miR-124-3p和NPY表达,并使用对抗体和对抗体操纵了miR-124-3p水平.

主要成果:

患有MDD的患者显示血清miR-124-3p升高,NPY降低,NPY,食欲和体重之间存在正相关性.
抑郁症模型表现出海马/皮层miR-124-3p的增加和NPY表达的减少.
抑制miR-124-3p增加了NPY并导致体重增加;激活miR-124-3p降低了NPY并导致体重减轻.

结论:

miR-124-3p负面调节NPY,调解抑郁症中的食欲抑制.
在MDD中,miR-124-3p/NPY轴是食欲的关键调节器.
针对这一轴,为MDD患者的食欲功能障碍提供了一个有希望的治疗策略.

关键词:

胃口胃口胃口身体重量体重体重抑郁症抑郁症抑郁症微型RNA-1243p是什么意思神经酸Y 神经酸Y

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