在早产和满期婴儿的肠道微生物组中微粒体的分布以及对宿主健康的影响

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Updated: Jan 17, 2026

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Anujit Sarkar¹, Maureen Groer¹, Thao T B Ho²

¹College of Nursing, The University of Tennessee, Knoxville, TN, United States.

Frontiers in pediatrics

|September 18, 2025

概括

在早产婴儿中发现了微粒体,某些物种的水平在2岁时增加. 需要进一步的研究来了解它们在婴儿发育中的作用.

科学领域:

微生物学微生物学
菌类学菌类学是指菌类学.
婴儿健康婴儿健康

背景情况:

微型菌是一种感染状动物的单细胞真菌,对免疫受损的个体构成风险.
这项研究调查了非常低出生体重 (VLBW) 和极低出生体重 (ELBW) 婴儿中微粒体的发生情况.
结果与一组数据集的婴儿样本进行了比较.

研究的目的:

调查VLBW和ELBW婴儿中微菌的发生和流行情况.
为了比较早产婴儿和早产婴儿中的微型菌的存在.
分析早产婴儿微粒体的纵向变化.

主要方法:

来自两个早产婴儿队列 (n=10和n=12) 在不同时间点的便样本的元基因组测序.
与已发表的期满婴儿队列进行比较 (n=19).
主要成分分析 (PCA) 和ALDEx2用于微生物组的比较和识别显著的微粒体物种差异.

主要成果:

在早产婴儿和早产婴儿之间没有显著的早期微型菌差异.
在2岁的早产儿中出现了显著的差异,其中*Mitosporidium daphniae*和*Nematocida homosporus*的水平更高.
*Encephalitozoon romaleae*和*Nosema ceranae*显示早产婴儿的患病率增加.从6周到2岁的早产婴儿患病率增加.

结论:

这项研究报告了人类生命早期第一次出现微粒体的情况.
一些微型菌物种在儿童时期持续存在并增加患病率.
由于样本规模小,研究结果需要谨慎解释;建议进行更大规模的研究.

关键词:

ELBW 婴儿婴儿的婴儿在VLBW婴儿婴儿.我们的肠道微生物组.转基因组学是指转基因组学.微型菌体微型菌体

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