综合炎症指标与差异化甲状腺癌的临床病理特征之间的关联
1Department of Medical Oncology, Brunch of Minhang, Fudan University Shanghai Cancer Hospital Shanghai, The People's Republic of China, Shanghai, China.
Frontiers in molecular biosciences
|September 18, 2025
概括
单细胞与淋巴细胞比率 (MLR) 升高,全身炎症反应指数 (SIRI) 和全身免疫炎症指数 (SII) 表明差异化甲状腺癌 (DTC) 的临床病理特征更差. 这些炎症标志物可以预测DTC患者的不良结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 分化甲状腺癌 (DTC) 管理从了解预后指标中获益.
- 像MLR,SIRI和SII这样的炎症标志物越来越多地被认为是它们在各种癌症中的作用.
研究的目的:
- 研究手术前的MLR,SIRI和SII与DTC患者的临床病理特征之间的关联.
- 探索这些炎症指数作为生物标志物的潜力,以改进DTC中的积极监测标准.
主要方法:
- 对231名DTC患者手术前的MLR,SIRI和SII值进行了回顾性分析.
- 通过临床病理学特征定义的各个子组的炎症标志物水平的比较.
- 根据中位数值进行低表达和高表达组的分类,以便进一步分析.
主要成果:
- 升高的SIRI和SII显著与较大的瘤大小,淋巴结转移和囊入侵有关.
- 高SIRI与较大的瘤直径和淋巴血管入侵相关.
- 高SII与侵袭性病理变异有关;MLR与大多数特征没有显著的关联,但与低表达组中较少的多焦点瘤有关.
结论:
- 手术前升高的MLR,SIRI和SII与DTC的不良临床病理特征有关.
- 这些炎症指数显示出潜在的预测生物标志物,用于识别具有不利特征的DTC患者.
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