在男性初级失眠中,大脑 - 边缘系统调节失调和感觉运动网络改变:休息状态功能磁共振成像研究
Juan Lu1, Zhengzhen Yuan2, Jidan Hu3
1Department of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Frontiers in human neuroscience
|September 18, 2025
概括
男性失眠患者表现出明显的脑活动模式,包括改变的低频波动和区域均性,特别是在感觉运动和小脑 - 边缘网络. 这些神经成像标记可能表明失眠,尽管与症状严重程度没有直接关联.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
背景情况:
- 在男性失眠障碍 (ID) 中的神经病理机制尚不清楚.
- 内在的大脑活动模式需要进一步调查.
研究的目的:
- 在使用fMRI的男性ID患者中研究低频波动 (ALFF) 和区域同质性 (ReHo) 的幅度.
- 探索神经成像指标和睡眠尺度得分之间的相关性.
主要方法:
- 招募了30名男性ID患者和30名健康对照 (HC).
- 管理的失眠严重程度指数 (ISI),匹兹堡睡眠质量指数 (PSQI) 和汉密尔顿抑郁量表 (HAMD).
- 使用静止状态fMRI (rs-fMRI) 进行ALFF和ReHo分析.
主要成果:
- ID患者的PSQI,HAMD和ISI得分高于HC患者.
- ID患者在前中心_R中显示ALFF降低,在大脑_6_R和时间_inf_L中显示ALFF增加.
- ID患者表现出时间_inf_L,大脑_6_R和海马_R的ReHo增加,并减少了Putamen_L,Insula_R和Calcarine_R的ReHo.
- 在ALFF/ReHo和临床规模得分之间没有发现显著的相关性.
结论:
- 男性ID患者在小脑-边缘和感觉运动网络中表现出功能异常.
- 这些变化可能与运动协调,情绪处理和感官整合受损有关.
- ALFF和ReHo模式可以作为ID的潜在生物标志物,独立于症状严重程度.
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