肠道微生物群随着生命周期的变化而变化 口服避孕的使用时间 使用口服避孕的使用时间
Gauri Paul1, Sayumi York2, Rosa Alcazar1
1Clovis Community College, Fresno, CA 93730, USA.
bioRxiv : the preprint server for biology
|September 18, 2025
概括
长时间使用口服避孕药 (OC) 与肠道细菌的变化有关,特别是有益的Clostridia的减少. 这种口服避孕药诱导的肠道微生物组转变可能会影响雌激素调节和妇女健康.
科学领域:
- 微生物组研究的研究.
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 口服避孕药 (OCs) 是女性广泛使用的.
- 肠道微生物组在激素代谢中起着重要作用.
- 对OC使用,肠道微生物群和荷尔蒙平衡之间的潜在联系尚未完全理解.
研究的目的:
- 调查终身口服避孕药 (OC) 使用时间对肠道微生物组合的影响.
- 为了确定与长时间的OC暴露相关的特定微生物变化.
- 探索OC使用,肠道细菌和雌激素调节之间的潜在机制.
主要方法:
- 从便样本中重新分析公开可用的16S rRNA测序数据.
- 对OC使用者和非使用者之间的微生物组成进行比较.
- 基于OC使用时间的统计分析来识别差异丰富的AMPLICON序列变异 (ASV).
主要成果:
- 确定了32个显著差异丰富的ASVs (padj<0.05) 与终身OC使用持续时间相关.
- 观察到16种属于Clostridia类的ASV随着OC使用持续时间的增加而下降.
- 突出了Clostridia在雌激素循环中的作用.
结论:
- 使用口服避孕药的终身持续时间显著改变了肠道微生物组合.
- 降低雌激素循环的克洛斯特里迪亚物种的丰富度,而OC使用时间较长,可能会影响激素调节.
- 肠道微生物组调制代表了一条潜在的途径,通过该途径,OC使用会影响妇女的健康.
相关概念视频
Anatomy of the Intestines
86.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.8K
Oogenesis
69.1K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
69.1K
Birth Control Methods
5.9K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.9K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
425
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
425
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Hormonal Regulation of the Menstrual Cycle
1.5K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.5K


