哺乳期的孕产妇运动会重新编程乳腺代谢中与肥胖相关的变化,以优化牛奶脂肪酸和后代的能量消耗
bioRxiv : the preprint server for biology
|September 18, 2025
概括
哺乳期的母体炼可以改善肥胖母亲的牛奶成分,促进婴儿脂肪氧化和能量消耗. 这强调了哺乳期是母亲活动影响后代代谢健康的关键时期.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 孕产妇的肥胖会对母乳成分产生负面影响,可能导致婴儿肥胖.
- 孕产妇运动对肥胖母亲的乳腺和牛奶脂质概况产生影响的机制尚未完全理解.
研究的目的:
- 为了研究母乳养期间的运动如何在肥胖小鼠中重塑乳腺上皮细胞 (MEC) 蛋白质和牛奶脂质特征.
- 为了确定母体运动诱导的牛奶成分变化对后代代谢的影响.
主要方法:
- 使用一种饮食诱导肥胖的小鼠模型,母乳在哺乳期间接受中度跑步机运动.
- 技术包括间接热量计,稳定同位素追踪器呼吸计和MEC蛋白质组学.
- 分析了牛奶的甘油三和脂肪酸成分.
主要成果:
- 孕产妇的肥胖改变了MEC蛋白质组,减少了脂肪酸合成酶,增加了牛奶中的甘油三含量以及omega-6和omega-3脂肪酸的比例.
- 孕产妇的运动增强了MEC的转化和囊泡运输通路,减少了脂肪酸脱,增加了乳中链脂肪酸 (MCFA),并部分纠正了肥胖女性的脂肪酸比率.
- 由运动肥胖的母乳养的后代显示全身能量消耗增加,脂肪酸氧化增强,以及改善代谢灵活性.
结论:
- 哺乳期的母体运动在肥胖的母体中重塑了乳腺新陈代谢和牛奶脂肪酸成分.
- 这些变化增强新生儿脂质氧化和能量消耗,表明哺乳期是母亲活动影响婴儿代谢健康的可修改窗口.
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